How Much Penicillin to Give a Dog?

How Much Penicillin to Give a Dog?- Dogs are incredibly active animals that enjoy being outdoors. Since they are almost always outside interacting with new elements in the environment, they are highly susceptible to infections caused by bacteria and viruses.

Such infections can also be caused due to changing seasons and several other factors. Your veterinarian may prescribe penicillin to resolve the issue, and as a responsible dog parent, you should know how much penicillin to give a dog.

To prevent your dog from entering the garden, consider the following steps:

  1. Create a physical barrier: Install a sturdy fence or use garden netting to block access to the garden area.
  2. Designate a dog-friendly area: Allocate a specific space within your yard where your dog can play and explore freely.
  3. Train and reinforce boundaries: Teach your dog commands like “Stay” or “Off” to establish boundaries around the garden.
  4. Provide alternative distractions: Offer toys, chew treats, or interactive puzzles to keep your dog mentally stimulated and less interested in the garden.
  5. Use deterrents: Utilize natural deterrents like citrus peels, vinegar, or pet-safe repellents to discourage your dog from entering the garden.
  6. Supervise and redirect: Monitor your dog’s behavior and redirect their attention to appropriate activities when they show interest in the garden.

To answer the question of today’s topic, all you need is the correct bodyweight of your dog in pounds and prompt following of your vet’s advice.

What is Penicillin?

Penicillins are a group of antibiotic drugs derived originally from the Penicillium fungi. Derivatives of the fungi are medically approved drugs like Penicillin V and Penicillin G, amongst others.

Scientifically referred to as Penicillin G, Pen G, Procaine Penicillin, or Benzylpenicillin, it is used to treat common bacterial infections. Penicillin G is injected into the veins or muscles of your dog or its chest cavity lining.

On the other hand, Penicillin V is an orally ingestible medicine prescribed in lower dosages to be used more frequently than pen G. Therefore, Pen G is more commonly defined as the dosage frequency is more bass and higher.

Both are used among humans and animals to treat medical issues caused by bacteria.

Not only are they used as a treatment, but they also have the ability to prevent bacterial infections when used appropriately, as advised by your vet.

Amoxicillin is the most commonly prescribed form of penicillin to treat pneumonia, ear, skin, and urinary tract infections caused due to bacteria. It is an antibiotic that is available only on prescription.

Veterinary Use of Penicillin

Penicillin has been proven effective by the US Food and Drug Administration. This federal authority oversees public health by regulating and supervising food supplies and drugs. It can be used for treating bacterial infections in various species like Dogs, cats, horses, cattle, and pigs.

In dogs, it may be used to treat

Urinary Tract Infections

Symptoms include pain while urinating, bleeding during urination, frequent licking of the genitals, etc.

Skin Infections

Flaking of the skin due to dryness, excessive hair loss in patches, swelling, pimples, etc., are signs of a skin infection caused by bacteria.

Ear Infections

Excessive scratching, swelling, and formation of crusts in the ear may be signs of a bacterial infection.

Oral Infections

Bleeding gums, discolored teeth, and foul mouth odor could be signs of a bacterial infection in your dog’s mouth.

Respiratory Infections

A nasal discharge could be an indication of an underlying bacterial infection that could lead to severe issues like pneumonia, kennel cough, etc.


Bacteria-induced fever can be brought under control by using penicillin to reduce high body temperature.

Infected Wounds

It is common for wounds to get infected by bacteria when left untreated. Upon early detection, the infection can be curbed by the use of common antibiotics like penicillin derivatives.

How Does it Work on Bacterial Infections?

Penicillin is only advised when it is definite that the infection can be treated with its usage or along with other drugs. It works by rupturing the cell walls of bacteria, which affects the cell walls of its offspring, making it easier to kill and helping to get rid of the bacteria effectively.

How Much Penicillin to Give a Dog?

Below are some of the precautions that need to be taken before giving your dog medication.

  1. It is always important to double-check with medical personnel about the dosage of any described drug. The dosage prescribed is affected by various factors such as your dog’s age, health conditions, etc.
  2. Penicillin is usually prescribed for no more than four days.
  3.  Do not go against your vet’s professional advice at any point in time. Stopping the dosage between the treatment period when you see improvement in your dog’s condition may prove fatal for your pet.
  4. Make sure that you give doses on time, and in case you miss the time, give your dog the amount immediately if it is not within 2 hours of the next dose. A window of a minimum of 2 hours between doses is required.
  5.  In case you are injecting your pet at home, ensure that you don’t inject the same site each time.
  6. Ensure that the contents of your injection are uniformly suspended and at room temperature before administering.
  7. Make sure to keep the drug out of your dog’s reach to avoid any mishaps in your absence and keep your pet safe.

How to Calculate dosage based on Your Dog’s Body Weight (Per Pound)?

The permitted daily dose of penicillin is 3000 units per pound of your dog’s body weight. When converted, it translates to 1 mL per 100 lbs of weight.

When converted into mg, it is safe to administer 5 mg per lbs body weight for most dogs.

The calculation for how much penicillin to give a puppy remains the same as for dogs. Ensure that you calculate the dose accurately for the antibiotic to show results.

Is Overdosing Possible?

Overdosing on the drug, although difficult, is possible. This is due to the high margin of safety. The legally approved dose is much lower than the amount that can harm your pet.

However, you must ensure that you administer only as per your vet’s advice to prevent any side effects, including diarrhea, excessive thirst, urination, allergic reactions, etc. When given in high enough doses, it could lead to kidney failure.

Therefore, it is essential to pay keen attention to your vet’s advice and read the information on the packaging of the medication to keep your dog safe.

What is the Form of Administration?

Penicillin can be administered in an injectable form or as oral ingestible tablets. If you are helping your dog dose by yourself, you must be careful about following every instruction and taking care of all the precautions advised by your vet.

The drug manufacturer in any form would also provide instructions regarding usage, which must be followed to ensure proper administration and to store to produce effective results.

How Long Does it Take to Show Effect?

Penicillin cannot be prescribed for more than four days. Follow your veterinarian’s advice regarding the dosages and frequency.

Your dog may show signs of improvement and better health within a couple of days before the end of the period. However, do not stop the doses.

This may be a sign of your dog’s body resisting the drug. The remaining amounts will eliminate the bacteria by the end of the treatment period.

What are the Side Effects of Giving Your Dog Penicillin?

Every drug has specific side effects that it may cause. Penicillin is no exception. Depending on the issue for which the medication has been prescribed, you may see different side effects. However, if you notice any unusual signs, immediately contact your vet.


If your dog has been prescribed penicillin to treat gastrointestinal issues, you may see your dog suffer from diarrhea as long as the treatment is advised.

This should slowly come to a stop by the end of the treatment period as a signal of effectiveness.

If you notice your dog suffering from diarrhea for a prolonged period, this may be a cause for worry that requires immediate medical attention.


 It is common for your dog to feel pain at the injection site for a while. However, contact your vet if the pain persists for long periods after injecting, which can be noticed by prolonged whimpering and a behavior change.

Skin Rashes

It is possible for your dog to be allergic to the drug. Keep a close lookout for common allergy signs such as skin rashes at the injection site.

Loss of Appetite and Vomiting

 These are definite signs of concern for an underlying problem that may have been caused due to penicillin. Usually, these symptoms are coupled with diarrhea.

Allergy Symptoms

These symptoms are relatively uncommon and occur only when your dog’s immune system fights against the drug.

Although these so-called allergens are threat-free, the immune system’s reaction may cause swelling of your dog’s face, tongue, hives, etc.

This is a sign that will become visible immediately after administering a dose of the drug.

Difficulty in Breathing

If your dog is showing signs of labored breathing, rush it to the vet immediately.

Itchiness and Redness

If your dog’s skin is red due to excessive itching since the beginning of the treatment, your dog could be sensitive to penicillin.


You may notice that your dog has been urinating less frequently since the beginning of the ordeal.

Dehydration is a common symptom that occurs along with diarrhea. You must ensure that your dog is hydrated all the time and regularly sips on cool, clean water to minimize the loss of water from its body.

Knowing how much penicillin to give a dog is essential, but it is far more necessary to understand the fatal symptoms to look out for.

If you notice any of these symptoms, ensure that you immediately take your dog to the veterinarian.

Penicillin allergies are prevalent, and if not taken seriously, they may lead to the failure of multiple systems in your dog’s body.

Aapt Dubey
Aapt Dubey

Aapt Dubey, a devoted canine enthusiast and experienced dog Owner, brings boundless passion to our team. With a heart full of love for our four-legged friends, Aapt is dedicated to sharing insights on dog care, behavior, and training to make every pup's life happier and healthier at

Know More

Recommended For You